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    Góc phố, thời gian và giá trị ngưng đọng
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    Giá trị
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    ABSTRACT The studies have investigated the immune response of gamma-irradiated Brucella spp., have been metabolically active and inactivated cells become able to induce a significant cellular immune response and were protective. Act as an adjuvant and increase the immune response for the foreign antigens. The researchers have developed the gamma-inactivated influenza vaccine, demonstrating that this vaccine is effective in eliciting a strong antigen-specific antibody response as well as protecting mice from challenge with heterologous influenza virus. Further, we propose that gamma-ray irradiation, that has been previously tested inactivation method, could be utilized to prepare an experimental COVID-19 vaccine that can provide balanced immunity of both B and T cells. The gamma-ray irradiation eliminated virus replication and preserve its infectivity and immunogenicity, even if membrane integrity has been reduced, can present the viral proteins to the immune system in a natural way, facilitating the induction of both T cell and humoral immunity. Membrane initiated nuclear signalling event help to kill infected cell also boost immunogenicity. The simplified, vaccine manufacturing protocols require cell culture virus growth, purification, and low-dose inactivation using a gamma ray source generally readily available for sterilization procedures of commercial products. This, of course, is important during a pandemic when enough vaccine doses are need to be manufactured with limited production capacity in a short time frame. Therefore, a gamma-ray irradiated virus vaccine could fulfil the unmet need for a safe, cost-effective, widely distributable COVID-19 vaccine. REFERENCES: 1) Sohini S. Bhatia and Suresh D. Pillai. Ionizing Radiation Technologies for Vaccine Development - A Mini Review. Front Immunol. 2022; 13:845514. 2022 Feb 11. Doi: 10.3389/fimmu.2022.845514. 2) (1) Z. Khatoon, R. K. Kale. Radiomodulation by Hoechst 33258 against Radiation induced damage in murine splenocytes. Indian Journal of Experimental Biology. (Indian J Exp Biol. 2012 Aug; 50 (8):517-30.). Doi: 10.6084/m9.figshare.27086008
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