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Anxiety disorders (ADs) are extremely common psychiatric conditions that frequently co-occur with other physical and mental disorders. The pathophysiology of ADs is multifaceted and involves intricate connections among biological elements, environmental stimuli, and psychological mechanisms. Recent findings have emphasized the importance of epigenetics in bridging the gap between various risk factors that contribute to ADs and improving our understanding of the pathomechanisms underlying ADs. Epigenetics is the study of how changes in the environment and behavior can have an impact on gene function. Indeed, researchers have found that epigenetic mechanisms can affect how genes either are activated or inactivated, as well as whether they are expressed. Such mechanisms can also influence in both the development and protection of ADs. That is, histone deacetylase inhibitors (HDACi) have been utilized in the majority of pharmacological trials testing epigenetic therapies for the treatment of ADs, showing promising results. In both preclinical and clinical pharmacological trials, HDACi have performed well in the treatment of ADs. In this review, we will present a summary of the current state of knowledge regarding putative risk mechanisms in the pathogenesis of ADs and the role of epigenetic mechanisms acting as potent factors in reducing disorder risk or treating ADs. In addition, we will review the information currently available from preclinical and clinical studies on the use of epigenetic medications to treat ADs.
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